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da Silva, AJ, Floquet, S, Santos, DOC and Lima, RF (2020)

On the validation of Newcomb-Benford law and Weibull distribution in neuromuscular transmission

Preprint.

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Abstract: The neuromuscular junction represents a relevant substrate for revealing important biophysical mechanisms of synaptic transmission. In this context, calcium ions are important in the synapse machinery, providing the nervous impulse transmission to the muscle fiber. In this work, we carefully investigated whether intervals of spontaneous electrical activity, recorded in seven different calcium concentrations, conform Newcomb-Benford law. Our analysis revealed that electrical discharge of neuromuscular junction obeys the expected values for Newcomb-Benford law for first and second digits, while first-two digits do not perfectly follows the law. We next examined previous theoretical studies, establishing a relation between the law and lognormal and Weibull distributions. We showed that Weibull distribution is more appropriate to fit the intervals as compared to lognormal distribution. Altogether, the present findings strongly suggest that spontaneous activity is a base-scale invariant phenomenon.


Bibtex:
@misc{, author = {Silva, Adriano and Floquet, Sergio and Santos, O.~C. and Lima, R.~F.}, year = {2020}, month = {01}, title = {On the validation of Newcomb-Benford law and Weibull distribution in neuromuscular transmission} URL = {https://www.researchgate.net/profile/Adriano_Silva41/publication/338409884_On_the_validation_of_Newcomb-Benford_law_and_Weibull_distribution_in_neuromuscular_transmission/links/5e1353d2299bf10bc392f63a/On-the-validation-of-Newcomb-Benford-law-and-Weibull-distribution-in-neuromuscular-transmission.pdf}, }


Reference Type: Preprint

Subject Area(s): Biology